منابع مشابه
Insights into Hydrate Formation and Stability of Morphinanes from a Combination of Experimental and Computational Approaches
Morphine, codeine, and ethylmorphine are important drug compounds whose free bases and hydrochloride salts form stable hydrates. These compounds were used to systematically investigate the influence of the type of functional groups, the role of water molecules, and the Cl(-) counterion on molecular aggregation and solid state properties. Five new crystal structures have been determined. Additio...
متن کاملStability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes
PURPOSE Determine the stability of fentanyl 10 mcg/mL in 0.9% sodium chloride, fentanyl 10 mcg/mL in 5% dextrose, fentanyl 50 mcg/mL, hydromorphone 100 mcg/mL in 0.9% sodium chloride, ketamine 10 mg/mL, midazolam 0.4 mg/mL in 5% dextrose, midazolam 5 mg/mL, morphine 1 mg/mL in 0.9% sodium chloride, morphine 1 mg/mL in 5% dextrose, and pentobarbital 50 mg/mL when stored as single drug entities a...
متن کاملRelative Oral Bioavailability of Morphine and Naltrexone Derived From Crushed Morphine Sulfate and Naltrexone Hydrochloride Extended-Release Capsules Versus Intact
© 2010 Excerpta Medica Inc. All rights reserved. ABSTRACT Background: Morphine sulfate/sequestered naltrexone hydrochloride (HCl) (MS-sNT) extended-release fixed-dose combination capsules, approved by the US Food and Drug Administration (FDA) in August 2009 for chronic moderate to severe pain, contain extendedrelease morphine pellets with a sequestered core of the opioid antagonist naltrexone. ...
متن کاملCompatibility and stability of morphine sulphate and naloxone hydrochloride in 0.9% sodium chloride for injection.
BACKGROUND Naloxone may be administered in conjunction with morphine to reduce the risk of opioid-induced pruritis. Combining these drugs for coadministration may be beneficial, but little is known about their physical compatibility and stability in combined solutions. OBJECTIVE To describe the physical compatibility and stability of morphine sulphate and naloxone hydrochloride (at various co...
متن کاملPatient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial.
CONTEXT Patient-controlled analgesia (PCA) with morphine is commonly used to provide acute postoperative pain control after major surgery. The fentanyl hydrochloride patient-controlled transdermal system eliminates the need for venous access and complicated programming of pumps. OBJECTIVE To assess the efficacy and safety of an investigational patient-controlled iontophoretic transdermal syst...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2012
ISSN: 1600-5368
DOI: 10.1107/s1600536812046405